"This site can’t be reached" After Local Update


after Local upgrade to 2.4 I have problems with All my websites.
All websites has “This site can’t be reached”, “ERR_CONNECTION_REFUSED” error.

I dont see problems in logs.
Virtualbox is running, app is running.
After update I’ve got few infos like " Environment update available! UPDATE ENVIRONMENT" but It doesnt help.

OS X 10.13.6
Any ideas?